Most psychotherapy outcome studies in the field of depression focus on changes in depressive symptoms and impairment of functioning. The present article reports on the General Life Functioning Scale (GLF), a measure of more positive aspects of a patient’s experience, specifically the patient’s sense of well-being and feeling that he or she can cope with problems that arise. The development of the GLF and psychometric data are presented, followed by outcome analyses and prediction of follow-up in the National Institute of Mental Health Treatment of Depression Collaborative Research Program. Although there were no significant outcome findings, the GLF at termination significantly predicted follow-up status, emphasizing the importance of considering the extent to which depressed patients make gains in positive aspects of experience.