Caregiving is a challenging yet rewarding life role that many individuals are called to fulfi ll for friends and family members. Research on caregiving for older adults has been growing rapidly in the past 30 years, identifying the many strains involved in as well as the positive outcomes of providing care. Only recently have studies in this area shed light on the experiences of sexual and gender minority caregivers and receivers. This body of research has illuminated the common challenges that face these individuals but also the unique stressors that they experience given their status. This chapter discusses the caregiving role in general as well as examines research specific to older lesbian, gay, bisexual, and transgender caregivers. The related topic of loss and bereavement as well as best practices and future directions with this population are also addressed.