This article broadens awareness about the resilience of indigenous women from one southeastern tribe in the United States and critically analyzes the societal constraints that have impaired their status and power. Throughout colonization, the centrality and authority experienced by indigenous women has been impaired by clashing beliefs and practices. Despite experiencing historical oppression, these women have continuously resisted colonial subjugation and have demonstrated resilience in response to adversity. Currently, some indigenous women are experiencing a resurgence of power and status, as they fill the highest ranks of political and leadership roles within their community.