The current study uses the dose-response model to examine the relationships between childhood victimization events and subsequent depression, symptoms of psychosis, and substance misuse in a sample of 230 randomly selected incarcerated women in the United States. Results on frequency of victimization were mixed. In this sample, both frequency of physical abuse and sexual abuse significantly predicted current symptoms of psychosis, only frequency of physical abuse significantly predicted substance misuse. Incarcerated women who experienced multi-victimization were 5.7 times as likely to report depression, 4.2 times as likely to report current symptoms of symptoms of psychosis, and 3.8 times as likely to meet criteria for a substance use disorder. Results indicate that adjusting prison-based interventions to address multi-victimization may improve outcomes and reduce recidivism among this population.